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Metabolomics in patients with phenylketonuria

Metabolomics in patients with phenylketonuria
  • Endocrinology and metabolism
  • Phenylketonuria (PKU)

Metabolomics in patients with phenylketonuria Uta Ceglarek (Germany)

Uta Ceglarek (Germany)

Patients with phenylketonuria (PKU) have to follow a lifelong phenylalanine restricted diet. This type of diet is accompanied by a reduced intake of saturated and unsaturated fatty acids especially long chain polyunsaturated fatty acids (LCPUFA). This study investigated whether the long-term fatty acid restriction influence mitochondrial fatty acid oxidation, sphingosine, cholesterol and PUFA metabolism. The conclusion was that  long-term dietary fatty acid restriction influenced energy production by mitochondrial beta-oxidation.

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Target audience
Specialists in pediatric, Dietitians, nutritionists, clinical biochemists, genetists, basic scientists, psychologists, Nurses, Healthcare professionals
by Excemed
Endocrinology and metabolism