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4th European Phenylketonuria Group (EPG) Symposium

4th European Phenylketonuria Group (EPG) Symposium
  • Endocrinology and metabolism
  • Phenylketonuria (PKU)
Symposium by Excemed
Friday, Mar 23 - Saturday, Mar 24 2012
Rome, Italy

Accreditation

EACCME®
Registration status
Closed

Target audiences

Specialists in pediatric
Dietitians
nutritionists
clinical biochemists
experts in genetics
basic scientists

Files

Overview

While dietary restriction of phenylalanine still remains the mainstay of treatment, phenylketonuria (PKU) is an active area of research, and new treatment options are emerging that may reduce the burden of a difficult and limiting diet in these patients and in their families. Basic and clinical research is now focusing on the mechanisms of action of new treatment options, like sapropterin dihydrochloride (also BH4), on monoamine neurotransmitters metabolism in the brain of PKU patients.

Furthermore there is an emerging need for evidence-based international guidelines to provide standardization in treatment initiation, in evaluation of the response to therapy with sapropterin dihydrochloride, and in blood phenylalanine concentration to target. A number of papers resulting from last year’s symposium reviewed the existing scientific evidences in several aspects of PKU, identifying the current positions in its management.

The European Phenylketonuria Group (EPG) and the Serono Symposia International Foundation (SSIF) consider it essential to continue their series of successful meetings on PKU, and have organized the 2012 Annual Symposium dedicated to that. The aims of this meeting are to review the most important outcomes of research in the field of PKU and to provide a forum for participants to discuss solutions that can optimize patient management in clinical practice.

Learning objectives

After attending this symposium, the participants will have up-to-date knowledge about:

  • Brain pathology of PKU
  • Blood-brain barrier and PKU
  • CNS neurotransmitters in PKU
  • Management of BH4 deficiency
  • Social and financial management of PKU
  • Amino acid status in PKU

Accreditation details

Serono Symposia International Foundation (www.seronosymposia.org) is accredited by the European Accreditation Council for Continuing Medical Education (EACCME®) to provide the following CME activity for medical specialists. The EACCME® is an institution of the European Union of Medical Specialists (UEMS), www.uems.net

The conference 4th European Phenylketonuria Group (EPG) Symposium “Advances and Challenges in PKU” (March 23-24, 2012 - Rome, Italy) is designated for a maximum of 8 (eight) hours of European CME credits (ECMEC). Each medical specialist should claim only those credits that he/she actually spent in the educational activity. EACCME® credits are recognized by the American Medical Association (AMA) towards the Physician's Recognition Award (PRA). To convert EACCME® credit to AMA PRA category 1 credit, please contact the AMA.

This program 4th European Phenylketonuria Group (EPG) Symposium “Advances and Challenges in PKU” (March 23-24, 2012 - Rome, Italy) has been submitted for CME accreditation from the Italian Ministry of Health (Ref. n. 12000620 - Medico chirurgo; Ref. n. 12000621 - Dietista

Additional information

Learning effectiveness project

Serono Symposia International Foundation is conducting a Learning effectiveness project at selected meetings during 2011. The meeting 4th European Phenylketonuria Group (EPG) Symposium: Advances and Challenges in PKU has been chosen to participate in this project.

Scientific programme

Friday March 23,2012

 

Special Lecture

 

Chairman: Harvey L. Levy, USA

 

PKU in Italy

Marcello Giovannini ,Italy

 

Session I Brain Pathology and neurotransmitters metabolism in PKU

 

Chairs: Ania C. Muntau, Germany; François Feillet, France

Mode of action of BH4 beyond blood Phe control

Nenad Blau, Germany

Bionformatic approaches in PKU research and implications for clinical management

Søren W. Gersting, Germany

 

Session II Oral communications

 

Chairs: Anita MacDonald, UK; Mübeccel Demirkol, Turkey

Molecular characterization and genotype- phenotype correlations in BH4-responsive PKU

Caroline Heintz, Switzerland

 

Parallel Workshop Sessions

 

Amino acids supplementation in PKU

Anita MacDonald UK; Margreet van Rijn, Netherlands

BH4 deficiencies_diagnosis and treatment

Alberto Burlina, Italy; Friedrich K. Trefz, Germany

How to improve adherence to PKU treatment

Francjan J. van Spronsen, Netherlands; Laurie Bernstein ,USA

 

 

 

Saturday March 24,2012

 

Session III Day to day experiences and treatment aspects in PKU

 

NIH PKU Conference Report: State of the science and future research needs

Harvey Levy, USA

 

Session V Asbjorn Folling Lecture and Award

 

Asbjorn Folling Lecture

Harvey L. Levy, USA

CME provider

Amaya Bélanger Quintana
Unidad de Enfermedades Metabólicas

Servicio de Pediatría

Hospital Ramón y Caja

Nenad Blau
Division of Clinical Chemistry and Biochemistry

University Children's Hospital

Zürich, Switzerland

Alberto Burlina
Division of Metabolic diseases

Department of Pediatrics

University Hospital Padua

Padua, Italy

Mübeccel Demirkol
Children's Hospital

Istanbul Faculty of Medicine

Istanbul University

Istanbul, Turkey

François Feillet
Centre de Référence des Maladies Héréditaires du Métabolisme

Hôpital d’Enfants, CHU Brabois

Vandoeuvre les Nancy, France

Anita MacDonald
Dietetic Department

The Children's Hospital

Birmingham, UK

Ania Muntau
Department of Molecular Pediatrics

Dr von Hauner Children's Hospital

Ludwig-Maximilians-University

Munich, Germany

Friedrich K. Trefz
Children’s Hospital

Kreis Kliniken Reutlingen GmbH

Klinikum Am Steinberg

School of Medicine University of Tuebingen

Reutlingen, Germany

Francjan J. van Spronsen
Beatrix Childrens Hospital

University Medical Center of Groningen

Groningen, The Netherlands

Chair(s)

Nenad Blau

Senior Consultant in Biochemical Genetics
Dietmar-Hopp-Metabolic Center
Division of Clinical Chemistry and Biochemistry
University Children's Hospital
Heidelberg, Germany

Faculty

Serono Symposia International Foundation adheres to guidelines of the European Accreditation Council for Continuing Medical Education (EACCME) and all other professional organizations, as applicable, which state that programs awarding continuing education credits must be balanced, independent, objective, and scientifically rigorous. Investigative and other uses for pharmaceutical agents, medical devices, and other products (other than those uses indicated in approved product labeling/package insert for the product) may be presented in the program (which may reflect clinical experience, the professional literature or other clinical sources known to the presenter). We ask all presenters to provide participants with information about relationships with pharmaceutical or medical equipment companies that may have relevance to their lectures. This policy is not intended to exclude faculty who have relationships with such companies; it is only intended to inform participants of any potential conflicts so participants may form their own judgments, based on full disclosure of the facts. Further, all opinions and recommendations presented during the program and all program-related materials neither imply an endorsement, nor a recommendation, on the part of Serono Symposia International Foundation. All presentations solely represent the independent views of the presenters/authors.

The following faculty provided information regarding significant commercial relationships and/or discussions of investigational or non-EMEA/FDA approved (off-label) uses of drugs:

Amaya Belanger-Quintana Declared to be member of Merck Serono PKU European Scientific Advisory Board, European Nutritionist Expert Panel and Kamper Advisory Board.

Laurie Bernstein Declared receipt of grants and contracts from Biomarin and Nutricia and of honoraria or consultation fees from Applied Nutrition and Nutricia.

Nenad Blau Declared receipt of research grants from Merck Serono and Biomarin Pharmaceutical Inc. and to be member of Merck Serono SA PKU advisory board.

Alberto Burlina Declared to be Kamper study Consultant.

Maureen Clearly Declared to be member of the European PKU Group sponsored by Merck Serono.

Mübeccel Dermikol Declared no potential conflict of interest.

François Feillet Declared receipt of honoraria or consultation fees from Genzyme, Biomarin, Merck Serono and Nutricia, and to be member of Merck Serono and Nutricia advisory Board.

Søren W. Gersting Declared receipt of grants and contracts from Merck Serono GmbH Darmstadt.

Bertold V. Koletzko Declared receipt of research grants by European Commission in partnership with SHS Scientific Hospital Supplies.

François Labarthe Declared receipt of honoraria or consultation fees as Member of the SPARK Steering Committee and that his presentation will include discussion on off-labeled use of BH4.

Vincenzo Leuzzi Declared no potential conflict of interest.

Harvey Levy Declared receipt of grants and contracts from BioMarin Pharmaceuticals. He declared that his presentation will discuss current off-labeled uses of products.

Anita MacDonald Declared receipt of research grants from Nutricia, Vitaflo, Cambrooke Foods and Merck, to be member of ENEP and Sapropterin Advisory Board, supported by Merck Serono and to be member of Nutricia ELEMENT (advisory board on IMD).

Ania C. Muntau Declared receipt of grants and contracts, of honoraria or consultation fees from Merck Serono and to be member of a Merck Serono advisory board.

Friedrich K. Trefz Declared receipt of honoraria or consultation fees from MerckSerono and to be member of the EPG and KAMPER advisory boards.

Margreet van Rijn Declared receipt of grants and contract from Nutricia Netherlands, of honoraria or consultation fees from SHS Nutricia Global – Danone and Merck Serono and to be member of the European Nutritionist Expert Panel of Merck Serono.

Francjan J. Van Spronsen Declared receipt of grants and contracts from Merck Serono, of honoraria or consultation fees form Merck Serono and Nutricia, to be member of Merck Serono and Nutricia advisory boards and participation in Merck Serono speaker’s bureau

The following faculty have provided no information regarding significant relationship with commercial supporters and/or discussion of investigational or non-EMEA/FDA approved (off-label) uses of drugs as of March 12, 2012.

Marcello Giovannini

Registration/Accommodation

Amaya Bélanger-Quintana

Unidad de Enfermedades Metabólicas

Servicio de Pediatría

Hospital Ramón y Cajal

Madrid, Spain

Nenad Blau
Division of Inborn Metabolic Diseases

University Children's Hospital

Department of General Pediatrics

Heidelberg, Germany

Alberto Burlina
Division of Metabolic diseases

Department of Pediatrics

University Hospital Padua

Padua, Italy

Mübeccel Demirkol
Children’s Hospital

Division Nutrition and Metabolism

Faculty of Medicine Istanbul University

Istanbul, Turkey

François Feillet
Centre de Référence des Maladies Héréditaires du Métabolisme

Hôpital d’Enfants, CHU Brabois

Vandoeuvre les Nancy, France

Anita MacDonald
Dietetics Department

Birmingham Children’s Hospital

Birmingham, UK

Ania Muntau
Departments of Inborn Errors of Metabolism and of Molecular Pediatrics

Dr. von Hauner Children’s Hospital

Ludwig-Maximilians-University

Munich, Germany

Friedrich K. Trefz
Medical Centre Gammertingen

Kreiskliniken Reutlingen GmbH

Gammertingen, Germany

Francjan J. van Spronsen
Beatrix Children’s Hospital

University Medical Center of Groningen (UMCG)

Groningen, Netherlands

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Endocrinology and metabolism
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Endocrinology and metabolism
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Endocrinology and metabolism
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Endocrinology and metabolism
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Endocrinology and metabolism
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Endocrinology and metabolism
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Endocrinology and metabolism
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Endocrinology and metabolism
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Endocrinology and metabolism