Serono Symposia International Foundation adheres to guidelines of the European Accreditation Council for Continuing Medical Education (EACCME) and all other professional organizations, as applicable, which state that programs awarding continuing education credits must be balanced, independent, objective, and scientifically rigorous. Investigative and other uses for pharmaceutical agents, medical devices, and other products (other than those uses indicated in approved product labeling/package insert for the product) may be presented in the program (which may reflect clinical experience, the professional literature or other clinical sources known to the presenter). We ask all presenters to provide participants with information about relationships with pharmaceutical or medical equipment companies that may have relevance to their lectures. This policy is not intended to exclude faculty who have relationships with such companies; it is only intended to inform participants of any potential conflicts so participants may form their own judgments, based on full disclosure of the facts. Further, all opinions and recommendations presented during the program and all program-related materials neither imply an endorsement, nor a recommendation, on the part of Serono Symposia International Foundation. All presentations solely represent the independent views of the presenters/authors.

The following faculty provided information regarding significant commercial relationships and/or discussions of investigational or non-EMEA/FDA approved (off-label) uses of drugs:

Amaya Belanger-Quintana Declared to be member of Merck Serono PKU European Scientific Advisory Board, European Nutritionist Expert Panel and Kamper Advisory Board.

Laurie Bernstein Declared receipt of grants and contracts from Biomarin and Nutricia and of honoraria or consultation fees from Applied Nutrition and Nutricia.

Nenad Blau Declared receipt of research grants from Merck Serono and Biomarin Pharmaceutical Inc. and to be member of Merck Serono SA PKU advisory board.

Alberto Burlina Declared to be Kamper study Consultant.

Maureen Clearly Declared to be member of the European PKU Group sponsored by Merck Serono.

Mübeccel Dermikol Declared no potential conflict of interest.

François Feillet Declared receipt of honoraria or consultation fees from Genzyme, Biomarin, Merck Serono and Nutricia, and to be member of Merck Serono and Nutricia advisory Board.

Søren W. Gersting Declared receipt of grants and contracts from Merck Serono GmbH Darmstadt.

Bertold V. Koletzko Declared receipt of research grants by European Commission in partnership with SHS Scientific Hospital Supplies.

François Labarthe Declared receipt of honoraria or consultation fees as Member of the SPARK Steering Committee and that his presentation will include discussion on off-labeled use of BH4.

Vincenzo Leuzzi Declared no potential conflict of interest.

Harvey Levy Declared receipt of grants and contracts from BioMarin Pharmaceuticals. He declared that his presentation will discuss current off-labeled uses of products.

Anita MacDonald Declared receipt of research grants from Nutricia, Vitaflo, Cambrooke Foods and Merck, to be member of ENEP and Sapropterin Advisory Board, supported by Merck Serono and to be member of Nutricia ELEMENT (advisory board on IMD).

Ania C. Muntau Declared receipt of grants and contracts, of honoraria or consultation fees from Merck Serono and to be member of a Merck Serono advisory board.

Friedrich K. Trefz Declared receipt of honoraria or consultation fees from MerckSerono and to be member of the EPG and KAMPER advisory boards.

Margreet van Rijn Declared receipt of grants and contract from Nutricia Netherlands, of honoraria or consultation fees from SHS Nutricia Global – Danone and Merck Serono and to be member of the European Nutritionist Expert Panel of Merck Serono.

Francjan J. Van Spronsen Declared receipt of grants and contracts from Merck Serono, of honoraria or consultation fees form Merck Serono and Nutricia, to be member of Merck Serono and Nutricia advisory boards and participation in Merck Serono speaker’s bureau

The following faculty have provided no information regarding significant relationship with commercial supporters and/or discussion of investigational or non-EMEA/FDA approved (off-label) uses of drugs as of March 12, 2012.

Marcello Giovannini