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Key players in the immunopathogenesis of MS

Key players in the immunopathogenesis of MS
  • Neurology
Multiple sclerosis


4 January 2017



Course introduction


This online course, prepared by Prof. Bernhard Hemmer, focuses on the key players in the immunopathogenesis of MS.

The immune system plays a central role in the pathogenesis of MS. The presence of lymphocytes and macrophages in MS lesions and the association of MS with HLA alleles and many genetic variants tagging particular immune genes define the adaptive immune system, which consists of T- and B-cells, as a key player in the pathogenesis of disease. In the progressive phase injury seems to arise from a compartmentalized immune response in the CNS, immune independent mechanisms of secondary degeneration as a consequence of earlier immune mediated damage or the combination of both mechanisms.

This course aims to provide an updated overview of all these processes subtending MS pathogenesis.

Learning objectives

By the end of this course participants will be able to:

  • Describe the B and T cells dysfunctional interaction in MS
  • Define the main factors linking genes, environment and autoimmune responses in MS
  • Illustrate the pathophysiological mechanisms subtentending compartimentalized inflammation and neurodegeneration in MS


Target audience

Healthcare professionals specializing in the MS field

Instructions for participation

Each slide in the course is accompanied by a video commentary from Prof. Hemmer. You may pause, repeat or skip sections as you wish. Please use the on-screen forward (right arrow) and backwards (left arrow) buttons to move through the presentation at your own speed. You may also jump to any slide you choose using the slide index.

Once you have completed the activity, you should undertake the final assessment test.

Once you have completed the activity, you should undertake the final assessment test. If you achieve a score of 80% or greater you will be able to download your certificate (EACCME CME accreditation for 1 European CME credit).


Bernhard Hemmer

Professor of Neurology and Director
Department of Neurology
University of Munchen
Munchen, Germany


Prof. Hemmer has been Director of the Department of Neurology of the Klinikum rechts der Isar at Technische Universität since 2007. He specializes in the field of neuroimmunology. His work focuses on research into B-cells and T-cells in inflammatory diseases of the central nervous system, especially multiple sclerosis (MS). Furthermore, he is investigating genetic factors relevant to the development and treatment of MS.

He is member of several clinical and research associations and has served as principal investigator in a number of multiple sclerosis treatment trials. His research is focused on immunology and genetics of multiple sclerosis. Prof Hemmer is spokesman for the Disease-oriented Competence Network for Multiple Sclerosis and is a member of the medical board of the German Multiple Sclerosis Society. He also serves as an executive board member of the International Society of Neuroimmunology (ISNI) and the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS).

Faculty disclosure

Disclosure of faculty relationships

All EXCEMED programmes are organized solely to promote the exchange and dissemination of scientific and medical information. No forms of promotional activities are permitted. There may be presentations discussing investigational uses of various products. These views are the responsibility of the named speakers, and do not represent an endorsement or recommendation on the part of EXCEMED. This programme is made possible thanks to an educational grant received from Merck KGaA, Darmstadt, Germany.

Prof. Hemmer has declared the receipt of honoraria or consultation fees from: Novartis and Roche. He also declared to be member of Novartis, Roche and Bayer's advisory board, board of directors or other similar group.