Diabetes and thyroid disorders are two of the most prevalent non-communicable chronic diseases worldwide, both having a heavy impact on patients’ quality of life and life expectancy. The number of people affected by diabetes mellitus is close to half a billion and the rising trend in diabetes prevalence worldwide is far from slowing, with catastrophic outcomes in terms of morbidity, mortality and healthcare expenditures. Type 2 diabetes, characterized by a systemic resistance to insulin action, is the most common form of diabetes mellitus. While efforts should be made to prevent overt diabetes, when this is not possible, a deep knowledge of the most up-to-date treatment strategies is crucial to ensuring a longer life expectancy and good quality of life for diabetic patients. Disorders in thyroid function are also very common and can lead to severe consequences if not promptly recognized and treated. Thyroid receptors have been found on several cell types, suggesting that thyroid hormones are involved in the regulation of the homeostasis of several tissues and organs. In particular, several studies have now clarified the relevant action of thyroid hormones on endothelial cells and cardiomyocytes. Indeed, even subclinical thyroid disorders are associated with adverse cardiovascular outcomes. In addition, thyroid nodules affect more than 50 percent of the general population, challenging the clinicians in daily clinical practice. This live educational programme has been organized by EXCEMED to review the most recent and significant research advances in the fields of pre-diabetes, diabetes and thyroid diseases, with the goal of having immediate clinical impact.