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The goal of personalized medicine is to tailor treatments to the patient’s individual biologic profile. In oncology, this concept has been reinvigorated by major achievements in therapeutic and molecular diagnostics. The exponential growth in understanding colorectal cancer biology has led to recent advancements in therapeutic strategy and predictability of added value for patients. The integration of precision medicine into medical oncology is transforming treatment algorithms which may ultimately translate knowledge into daily clinical practice, while leading to a more collaborative disease management approach among disciplines.
• Recapitulate colorectal cancer biology and select molecular tests of clinical relevance
• Evaluate biomarker-driven strategies and establish a “continuum of care” in patients with colorectal cancer
• Implement the design and interpretation of clinical trials in colorectal cancer
SESSION I
09.15 Introduction
A. Sobrero (Italy)
09.30 L1: Management of advanced colorectal cancer VIDEO LECTURE
A. Sobrero (Italy)
10.00 L2: Molecular determinants for first-line treatment in mCRC VIDEO LECTURE
C.H. Köhne (Germany)
This lecture will be graphically recorded
10.30 L3: Second-line treatment and beyond in mCRC
A. Sobrero (Italy)
This lecture will be graphically recorded
11.00 Coffee Break
11.15 Working groups
Clinical cases solving
C.H. Köhne (Germany); F.S. Papadia (Italy); A. Sobrero (Italy)
12.45 Question time
13.00 Lunch
SESSION II
14.00 L4: Dominant molecular pathways in CRC VIDEO LECTURE
R. Dienstmann (Spain)
14.30 L5: Tumor heterogeneity VIDEO LECTURE
P. Gazzaniga (Italy)
This lecture will be graphically recorded
15.00 L6: Colorectal molecular subtypes and beyond VIDEO LECTURE
R. Dienstmann (Spain)
15.30 Coffee Break
15.45 L7: Tissue sampling bias and liquid biopsy
P. Gazzaniga (Italy)
This lecture will be graphically recorded
16.15 Question time
16.30 PATIENT MANAGEMENT
Molecular oncology & Medical oncology: interprofessional dialogues
R. Dienstmann (Spain); P. Gazzaniga (Italy);
C.H. Köhne (Germany); A. Sobrero (Italy)
17.15 End of the first day
09.15 Wrap-up time
09.30 L8: Three versus six months adjuvant chemotherapy in stage III colon cancer
A. Sobrero (Italy)
10.00 L9: To treat or not to treat stage II CRC
C.H. Köhne (Germany)
10.30 Coffee Break
10.45 Working groups
Clinical cases solving
C.H. Köhne (Germany); F.S. Papadia (Italy); A. Sobrero (Italy)
11.15 L10: Evolving clinical trial design in CRC
R. Dienstmann (Spain)
This lecture will be graphically recorded
11.45 L11: Interpretation of clinical trials results
A. Sobrero (Italy)
This lecture will be graphically recorded
12.15 CLINICAL TRIALS
Molecular oncology & Medical oncology: interprofessional dialogues
R. Dienstmann (Spain); P. Gazzaniga (Italy);
C.H. Köhne (Germany); A. Sobrero (Italy)
This interprofessional dialogue will be graphically recorded
13.00 Concluding remarks
End of the course
Closing Lunch