It is well established that high blood pressure is the most important cardiovascular risk factor and the leading cause of death worldwide. In the near future the prevalence of hypertension will increase worldwide despite the global effort to combat this important disease. Recent American and European Guidelines for hypertension have stimulated discussion about on defining more ambitious targets for antihypertensive treatment, thereby supporting the need for more aggressive treatment. On the other hand, it is necessary to examine whether study results supporting the new targets, including the SPRINT trial, are truly applicable in clinical practice. Another new aspect raised by Guidelines is the primary role of fixed-dose combination therapy. It is therefore necessary to examine all the different available combinations to understand their differences and specific indications. EXCEMED has designed a comprehensive Blended Learning Journey to increase knowledge in cardiovascular disease with a specific focus on hypertension. This programme will address the most recent advancements of research in the area of this cardiovascular risk factor and will discuss the best approach for clinical management of the complex hypertensive patient in daily practice. A multistep approach will be used, encompassing web-based and live activities. All activities – in-person and online – will involve the full interaction of learners.