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Imaging of remyelination in multiple sclerosis (MS)

Imaging of remyelination in multiple sclerosis (MS)
  • Neurology
Multiple sclerosis


8 November 2017




This online course, prepared by Prof. Bruno Stankoff MD PhD, focuses on the biological and cellular mechanisms behind remyelination and of the imaging techniques, both in use and under development, for measuring remyelination dynamics.

Remyelination occurs in response to any myelin damage in the CNS. Studies have demonstrated that in animal models of multiple sclerosis (MS), remyelinating processes are less efficient due to a lack of differentiation of oligodendrocytes.

Currently, little is known about the dynamics of remyelination in human MS, as there is a lack of sensitive and specific imaging tools for measuring myelin repair. However, new imaging techniques such as positron emission tomography (PET) are under development, with promising results. Imaging the dynamics of remyelination is critical for the discovery of prognostic markers, and for measuring the effect of pro-myelinating and anti-inflammatory treatments.

Learning objectives

By the end of this course participants will:

  • understand the cellular and molecular mechanisms associated with demyelination and remyelination in multiple sclerosis
  • be able to illustrate the key principles of imaging techniques suitable for investigating demyelination and remyelination
  • be aware of the future application of dynamic imaging of remyelination

Target audience

Neurologists and neuroradiologists with expertise in Multiple Sclerosis.

Instructions for participation

Each slide in the course is accompanied by a video commentary from Prof. Stankoff. You may pause, repeat or skip sections as you wish.

You will need to answer some multiple choice questions before you view the slides. Once you have completed the activity, you should undertake the final assessment test. If you achieve a score of 80% or greater you will be able to download a certificate of completion for your records.


The Imaging of remyelination in MS, made available on and organized by EXCEMED, is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists.

Each medical specialist should claim only those credits that he/she actually spent in the educational activity. The EACCME is an institution of the European Union

of Medical Specialists (UEMS). Only those e-learning materials that are displayed on the UEMS-EACCME website have formally been accredited.

Through an agreement between the European Union of Medical Specialists (UEMS) and the American Medical Association (AMA), physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits TM .

Information on the process to convert EACCME credit to AMA credit can be found at