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  1. Aggressive “case finding” is warranted for subclinical hypothyroidism

    ... and aggressive testing of thyroid-stimulating hormone (TSH) levels to identify high-risk individuals. 1 The case histories below ... to the gynaecologist when she was 8 weeks pregnant. A TSH test was ordered, which showed a level of 4.5 mU/L. As this patient’s ...

  2. Recommended reading – key published papers from 2017 as chosen by our Scientific Committee Members

    ... randomized to receive either placebo or levothyroxine with a TSH target of 0.40 to 4.60 mIU/L. The two primary outcomes were the change in ... symptoms. However, few participants had a baseline TSH level of more than 10 mIU/L and it was underpowered to detect any effect of ...

  3. Highlights of the 39th European Thyroid Association Annual Meeting

    ... the transmembrane region of the thyroid-stimulating hormone (TSH) receptor were discussed by Marvin Gershengorn (National Institute of ... symposium on cell-based bioassays for measuring functional TSH-receptor stimulating and blocking autoantibodies was held on Sunday ...

  4. Thyroid disease in the elderly – the basics

    ... to population studies, thyroid stimulating hormone ( TSH ) levels increase slightly as age advances. This is interpreted as an age-related alteration in the TSH set point – or reduced TSH bioactivity – rather than occult ...

  5. Thyroid dysfunction and cardiovascular risk

    ... with undetectable serum thyroid stimulating hormone ( TSH ; HR 1.94, CI 1.01–3.72). 11,16 Interestingly, autoimmune ... (Table 2) . Subclinical hypothyroidism with TSH >10 mU/L is an important risk factor for heart failure in older adults. ...

  6. Thyroid dysfunction: Frequently asked questions among patients

    ... by also measuring levels of thyroid stimulating hormone ( TSH ), which is produced in the brain and acts on the thyroid gland to stimulate T4 and T3 production. If TSH is high, then thyroid gland hormone secretion is the primary defect. ...

  7. Recommended reading

    ... Y, Olivo P, Kahaly GJ. Standardization of a bioassay for TSH receptor stimulating autoantibodies . Thyroid 2014; Oct 15. [Epub ahead ... D, Guttler RB, LoPresti JS, Nicoloff JT. Thyrotropin ( TSH )-releasing hormone stimulation test responses employing third and fourth ...

  8. Congress Report: Highlights from the 2017 annual meeting of the American Thyroid Association (ATA 2017)

    ... metabolism and basic thyroidology. In a seminar on TSH receptor autoantibodies, Dr Tanja Diana , (Molecular Thyroid and ... accurate measurement of specific stimulating and blocking TSH receptor antibodies. These functional antibodies are excellent biomarkers ...

  9. Hypothyroid patients are not all the same: Part 1 – Issues in levothyroxine replacement

    ... of hypothyroidism, degree of thyroid stimulating hormone ( TSH ) elevation, presence of cardiac disease and, in women, pregnancy status. ... dose is titrated upward gradually, using serum TSH as a goal. Age is a very important consideration in levothyroxine ...

  10. Thyroid disease in the elderly

    ... in patients <70 years with subclinical hypothyroidism ( TSH 5-10 MU/L) and treated with levothyroxine versus those not treated. This ... agree that patients >65 years should only be treated when TSH levels rise above 10 mU/L. 5-7 A randomized clinical trial by the ...

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