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  1. Congress Report: ENDO 2015

    ... salient points: Based on recent data from the Cancer Gene Atlas Consortium, thyroid cancer in general has low mutation rates. ... classified as BRAF-like or RAS-like with relatively distinct gene expression, mRNA profile, and methylation and proteomic patterns. ...

  2. Report on the Annual Meeting of the European Thyroid Association

    ... of the RET mutation. Molecular profiling Gene -expression profiles and divergent roles of forkhead family transcription ... role of further mutations e.g. the ERBB2, NRAS and P13KCA gene mutations are being currently evaluated. All in all, this was an ...

  3. Recommended reading

    ... Dittmar M, Woletz K, Kahaly GJ. Reduced DNASE1 gene expression in thyroid autoimmunity. Horm Metab Res 2013; 45: 257-60. ... of a novel splice donor site mutation in the thyroglobulin gene. J Clin Endocrinol Metab 2006; 91: 740-6. Link to PubMed ... M. Mutations in critical domains confer the human mTOR gene strong tumorigenicity. J Biol Chem 2013; 288: 6511-21. Link to PubMed ...

  4. Congress Report: ENDO 2016

    ... mRNA-based classifier (Rosetta GX™) 7 Gene Panel ( BRAF , RAS , RET/PTC , PAX8/PPARy ) ThyroSeq®-enhanced gene panel Afirma® gene expression classifier mRNA-based testing ...

  5. Congress Report: Highlights from the 86th Annual Meeting of the American Thyroid Association

    ... (NIH, Bethesda, USA) used microarray analysis of intestinal gene expression during metamorphosis to show that Mad expression is induced by ... This action inhibits BET-activated transcription of the Myc gene. In the translational field of thyroid cancer, the notion that T1a ...

  6. Scientific Highlights from the 2015 International Thyroid Association Congress

    ... that genetic-epigenetic dysregulation of thymic TSHR gene expression may facilitate the escape of TSHR-reactive T cells from central ... functions. Two families with mutations in the THRalpha gene were first identified in 2012 by two research groups, one from ...

  7. Congress Report: 16th Latin American Thyroid Society (LATS)

    ... non-coding RNA molecules involved in the regulation of gene expression. Low expression of miR-451a has been shown to correlate with ...

  8. Recommended reading – key published papers from 2017 as chosen by our Scientific Committee Members

    ... not reverse the ligand-independent action of the TR on many gene targets. Thus, many of the genomic changes mediated by the TR in ...

  9. Scientific Highlights: 2016 Asia Pacific conference on thyroid diseases - clinical features and management

    ... of suspicious/atypical cases. Molecular testing, includes gene mutation analysis, next generation sequencing, gene expression profiling and microRNA profiling of thyroid fine needle ...

  10. Thyroid dysfunction and cardiovascular risk

    ... Ladenson PW et al . Reversible alterations in myocardial gene expression in a young man with dilated cardiomyopathy and hypothyroidism. ...

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