This new package of video lectures features three international experts on fundamental aspects of multiple sclerosis. Taken from the Session I of the recent 2017 Annual Conference in MS.

Diego Centonze (Italy)
Immunological signatures in relapsing remitting and progressive MS
Prof Centonze explains the role of the innate and acquired immune systems in MS development and progression. He also looks at the roles of B and T cells in sustaining and amplifying peripheral inflammation in relapsing remitting and progressive MS and describes the deregulation of serum pro- and anti-inflammatory cytokines in RR and progressive MS.

Amit Bar-Or (USA)
The Compartmentalized Immune Responses in MS
Prof Bar-Or Illustrates the anatomical localization of immune cell infiltrates in the central nervous system (CNS), the main route of CNS infiltration and histopathological findings. He describes the molecular mechanisms through which the compartmentalized immune response contributes to MS progression. In addition, he sheds light on the role of microglia with respect to inflammation and neurodegeneration.

Jan Hillert (Sweden)
Neuroinflammation: role of genes and environment
Prof Hillert looks at the main environmental risk factors associated with MS and illustrates the genetic variants and alleles associated with heightened risk of developing MS and/or specific MS clinical phenotypes. He also describes mechanisms linking genetic and environmental risk factors with the development of neuroinflammation.